diff --git a/e2e_tests/tests/block.rs b/e2e_tests/tests/block.rs
index b3732085c3..1a82a03aa0 100644
--- a/e2e_tests/tests/block.rs
+++ b/e2e_tests/tests/block.rs
@@ -7,9 +7,11 @@
 pub mod fixture;
 
 use std::env;
+use std::path::Path;
 use std::process::Command;
 use std::time;
 
+use fixture::vhost_user::CmdType;
 use fixture::vhost_user::Config as VuConfig;
 use fixture::vhost_user::VhostUserBackend;
 use fixture::vm::Config as VmConfig;
@@ -37,6 +39,7 @@ fn prepare_disk_img() -> NamedTempFile {
     disk
 }
 
+/// Tests virtio-blk device is mountable.
 // TODO(b/243127498): Add tests for write and sync operations.
 #[test]
 fn mount_block() {
@@ -55,6 +58,7 @@ fn mount_block() {
     );
 }
 
+/// Tests `crosvm disk resize` works.
 #[test]
 fn resize() {
     let disk = prepare_disk_img();
@@ -112,23 +116,36 @@ fn resize() {
     );
 }
 
-#[test]
-fn vhost_user_mount() {
-    let disk = prepare_disk_img();
-    let disk_path = disk.path().to_str().unwrap().to_string();
-    let socket = NamedTempFile::new().unwrap();
-    let socket_path = socket.path().to_str().unwrap().to_string();
+fn create_vu_config(cmd_type: CmdType, socket: &Path, disk: &Path) -> VuConfig {
+    let socket_path = socket.to_str().unwrap();
+    let disk_path = disk.to_str().unwrap();
     println!("disk={disk_path}, socket={socket_path}");
+    match cmd_type {
+        CmdType::Device => VuConfig::new(cmd_type, "block").extra_args(vec![
+            "block".to_string(),
+            "--socket".to_string(),
+            socket_path.to_string(),
+            "--file".to_string(),
+            disk_path.to_string(),
+        ]),
+        CmdType::Devices => VuConfig::new(cmd_type, "block").extra_args(vec![
+            "--block".to_string(),
+            format!("vhost={},path={}", socket_path, disk_path),
+        ]),
+    }
+}
 
-    let vu_config = VuConfig::new("block").extra_args(vec![
-        "--socket".to_string(),
-        socket_path.clone(),
-        "--file".to_string(),
-        disk_path,
-    ]);
+fn run_vhost_user_test(cmd_type: CmdType) {
+    let socket = NamedTempFile::new().unwrap();
+    let disk = prepare_disk_img();
+
+    let vu_config = create_vu_config(cmd_type, socket.path(), disk.path());
     let _vu_device = VhostUserBackend::new(vu_config).unwrap();
 
-    let config = VmConfig::new().extra_args(vec!["--vhost-user-blk".to_string(), socket_path]);
+    let config = VmConfig::new().extra_args(vec![
+        "--vhost-user-blk".to_string(),
+        socket.path().to_str().unwrap().to_string(),
+    ]);
     let mut vm = TestVm::new(config).unwrap();
     assert_eq!(
         vm.exec_in_guest("mount -t ext4 /dev/vdb /mnt && echo 42")
@@ -137,3 +154,15 @@ fn vhost_user_mount() {
         "42"
     );
 }
+
+/// Tests vhost-user block device with `crosvm device`.
+#[test]
+fn vhost_user_mount() {
+    run_vhost_user_test(CmdType::Device);
+}
+
+/// Tests vhost-user block device with `crosvm devices` (not `device`).
+#[test]
+fn vhost_user_mount_with_devices() {
+    run_vhost_user_test(CmdType::Devices);
+}
diff --git a/e2e_tests/tests/fixture/vhost_user.rs b/e2e_tests/tests/fixture/vhost_user.rs
index 15a4fde1f0..20035f4c6d 100644
--- a/e2e_tests/tests/fixture/vhost_user.rs
+++ b/e2e_tests/tests/fixture/vhost_user.rs
@@ -12,22 +12,41 @@ use anyhow::Result;
 
 use crate::fixture::utils::find_crosvm_binary;
 
-#[derive(Default)]
-pub struct Config {
-    dev_name: String,
+pub enum CmdType {
+    /// `crosvm device` command
+    Device,
+    /// `crosvm devices` command that is newer and supports sandboxing and multiple device
+    /// processes.
+    Devices,
+}
 
+impl CmdType {
+    fn to_subcommand(&self) -> &str {
+        match self {
+            // `crosvm device`
+            CmdType::Device => "device",
+            // `crosvm devices`
+            CmdType::Devices => "devices",
+        }
+    }
+}
+
+pub struct Config {
+    cmd_type: CmdType,
+    dev_name: String,
     extra_args: Vec<String>,
 }
 
 impl Config {
-    pub fn new(name: &str) -> Self {
+    pub fn new(cmd_type: CmdType, name: &str) -> Self {
         Config {
+            cmd_type,
             dev_name: name.to_string(),
-            ..Default::default()
+            extra_args: Default::default(),
         }
     }
 
-    /// Uses extra arguments for `crosvm devices $dev_name`.
+    /// Uses extra arguments for `crosvm (device|devices)`.
     pub fn extra_args(mut self, args: Vec<String>) -> Self {
         self.extra_args = args;
         self
@@ -43,7 +62,7 @@ pub struct VhostUserBackend {
 impl VhostUserBackend {
     pub fn new(cfg: Config) -> Result<Self> {
         let mut cmd = Command::new(find_crosvm_binary());
-        cmd.args(&["device", &cfg.dev_name]);
+        cmd.args(&[cfg.cmd_type.to_subcommand()]);
         cmd.args(cfg.extra_args);
 
         cmd.stdout(Stdio::piped());